pMGMTme-Luc MGMT啟動子甲基化熒光報告質粒載體

A MGMT methylated glioblastoma allows for a better patient response to treatments, specifically temozolomide and radiation. MGMT (O6-methylguanine-DNA methyltransferase) is a special enzyme that can repair damaged DNA. While MGMT protects normal cells, it, unfortunately, also protects tumor cells from chemotherapy. Promoter methylation of O6-methylguanine-DNA methyltransferase (MGMT) is an important predictive biomarker in glioblastoma. The T variant of the MGMT promoter-enhancer single nucleotide polymorphism (SNP; rs16906252) has been associated with the presence of MGMT promoter methylation in other cancers.

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