ABCA1基因表達質粒慢病毒載體熒光質粒 BioVector NTCC質粒載體菌種細胞基因保藏中心
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- 貨 號:ABCA1基因表達質粒慢病毒載體熒光質粒
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ABCA1基因表達質粒慢病毒載體熒光質粒
RefSeq NM_005502.2, NM_005502.3, NP_005493.2
RefSeq Size 10515 bp
RefSeq ORF 6786 bp
Locus ID 19
Cytogenetics 9q31.1
Protein Families Druggable Genome, Transmembrane
Protein Pathways ABC transporters
MW 254.3 kDa
Gene Summary The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in both alleles of this gene cause Tangier disease and familial high-density lipoprotein (HDL) deficiency.
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