中文名稱：馬妥珠單抗

中文同義詞：馬妥珠單抗

英文名稱：Matuzumab

英文同義詞：Emd72000；EChemicalbookmd-72000；Kgaa；Merckkgaa；Matuzumab；Matuzumab-10mg/ml

產(chǎn)品描述

馬妥珠單抗類似物是抗人EGFR的人源化IgG1單克隆抗體，含有約10%的鼠源序列，具有較低的免疫原性，具有IgG1的誘導(dǎo)抗體依賴性細(xì)胞毒性的能力，由中國倉鼠卵巢細(xì)胞生產(chǎn)。


本公司供應(yīng)的馬妥珠單抗類似物原液是一種無菌、無熱源、不含防腐劑、澄清的無色溶液，含有10mg/ml的馬妥珠單抗和20mMtris緩沖鹽。


注：本產(chǎn)品僅限科研使用，不得用于人體試驗(yàn)和治療！


性質(zhì)


Name


Biosimilar of Matuzumab

CAS NO.


339186-68-4

Type


Whole antibody

Source


Humanized

Target


EGFR

Clone


Monoclone

Antibody Form


Purified immunoglobulin

Physical Form


Solution

Grade Standard


Medicine Grade

Storage


-70±15℃ for long-term storage, 2-8℃ for short-term storage, away from light.

生物活性

馬妥珠單抗Matuzumab binds to epidermal growth factor receptor (EGFR) on the outer membrane of normal and tumor cells. The matuzumab epitope has been mapped to domain III of the extracellular domain of the EGFR. The EGFR is receptor tyrosine kinase which binds multiple growth factors including EGF (epidermal growth factor) and other members of the EGF family of growth factors, resulting in activation of its tyrosine kinase activity. Activation of the EGFR has diverse effects on target cells depending on cell type and tissue context. It directs cell fate decision relating to cell growth, survival and, differentiation. Development of matuzumab and other antibodies to the EGFR (for example cetuximab) as cancer therapeutics was motivated by observations that EGFR expression and/or signaling is frequently upregulated in cancer cells.
不同實(shí)驗(yàn)動(dòng)物依據(jù)體表面積的等效劑量轉(zhuǎn)換表（數(shù)據(jù)來源于FDA指南）

小鼠 大鼠 兔 豚鼠 倉鼠 狗
重量 (kg) 0.02 0.15 1.8 0.4 0.08 10
體表面積 (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km 系數(shù) 3 6 12 8 5 20
動(dòng)物 A (mg/kg) = 動(dòng)物 B (mg/kg) × 動(dòng)物 B的Km系數(shù)
動(dòng)物 A的Km系數(shù)

例如，依據(jù)體表面積折算法，將白藜蘆醇用于小鼠的劑量22.4 mg/kg 換算成大鼠的劑量，需要將22.4 mg/kg 乘以小鼠的Km系數(shù)（3），再除以大鼠的Km系數(shù)（6），得到白藜蘆醇用于大鼠的等效劑量為11.2 mg/kg。

單抗藥物對(duì)照品
貝伐單抗，Bevacizumab 納武單抗，Nivolumab
帕妥珠單抗，Pertuzumab 曲妥珠單抗，Trastuzumab
阿達(dá)木單抗，Adalimumab 帕姆單抗，Pembrolizumab
迪諾蘇單抗，Denosumab 阿替唑單抗，Atezolizumab
優(yōu)特克諾單抗，Ustekinumab 維多珠單抗，Vedolizumab
1、33個(gè)產(chǎn)品，三種規(guī)格：1mg，2mg，5mg；
2、價(jià)格優(yōu)，全現(xiàn)貨；
3、科研產(chǎn)品，僅用科研，禁用臨床；

Supplier供應(yīng)商：BioVector NTCC質(zhì)粒載體菌株細(xì)胞蛋白抗體基因保藏中心
電話：010-53513060
網(wǎng)址http://www.biovector.net