中文名稱：OMALIZUMAB

中文同義詞：奧馬珠單抗

英文名稱：OMALIZUMAB

英文同義詞：OMALIZUMAB；Xolair；Omalizumab - buffer solution

產品描述

奧馬珠單抗類似物是一種選擇性與人IgE結合的重組DNA人源化單克隆抗體，分子量約149kDa，由中國倉鼠卵巢細胞懸浮培養生產。

性質


Name


Biosimilar of Omalizumab

CAS NO.


242138-07-4

Type


Whole antibody

Source


Humanized (from mouse)

Target


IgE Fc region

Clone


Monoclone

Molecular Weight


149 kDa

Formula


C6450H9916N1714O2023S38

Antibody Form


Purified immunoglobulin

Physical Form


Solution

Grade Standard


Medicine Grade

Storage


-70±15℃ for long-term storage, 2-8℃ for short-term storage, away from light.

生物活性

奧馬珠單抗Omalizumab is a recombinant DNA-derived humanized IgG1k monoclonal antibody that specifically binds to free human immunoglobulin E (IgE) in the blood and interstitial fluid and to membrane-bound form of IgE (mIgE) on the surface of mIgE-expressing B lymphocytes. Omalizumab inhibits the binding of IgE to FcεRI on mast cells and basophils by binding to an antigenic epitope on IgE that overlaps with the site to which FcεRI binds. When IgE is bound to the receptor, the antigenic epitope on IgE to which omalizumab binds is sterically hindered by the receptor and is not accessible to omalizumab binding, thus averting the anaphylactic effects presumably unavoidable with an ordinary anti-IgE antibody . Furthermore, although the peptide elements on IgE involved in binding to low affinity IgE receptor (FcεRII) on many cell types are different from the peptide elements involved in binding to FcεRI, omalizumab, by steric hindrance, also prevents binding of IgE to FcεRII.
不同實驗動物依據體表面積的等效劑量轉換表（數據來源于FDA指南）

小鼠 大鼠 兔 豚鼠 倉鼠 狗
重量 (kg) 0.02 0.15 1.8 0.4 0.08 10
體表面積 (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km 系數 3 6 12 8 5 20
動物 A (mg/kg) = 動物 B (mg/kg) × 動物 B的Km系數
動物 A的Km系數

例如，依據體表面積折算法，將白藜蘆醇用于小鼠的劑量22.4 mg/kg 換算成大鼠的劑量，需要將22.4 mg/kg 乘以小鼠的Km系數（3），再除以大鼠的Km系數（6），得到白藜蘆醇用于大鼠的等效劑量為11.2 mg/kg。
儲備液配制

以下數據基于產品分子量，對于特殊產品，請參照COA中的儲備液配制條件和說明進行操作。
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.0069 mL 0.0345 mL 0.0689 mL
5 mM 0.0014 mL 0.0069 mL 0.0138 mL
10 mM 0.0007 mL 0.0034 mL 0.0069 mL
參考文獻

Anti-IgE antibodies for the treatment of IgE-mediated allergic diseases.
Chang TW, et al. Adv Immunol. 2007;93:63-119. PMID: 17383539.

Development of a monoclonal anti-immunoglobulin E antibody (omalizumab) for the treatment of allergic respiratory disorders.
Schulman ES. Am J Respir Crit Care Med. 2001 Oct 15;164(8 Pt 2):S6-11. PMID: 11704611

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1、33個產品，三種規格：1mg，2mg，5mg；
2、價格優，全現貨；
3、科研產品，僅用科研，禁用臨床；

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