Talin 1 (TLN1) gene基因表達質粒敲除編輯載體

RefSeq NM_006289.4
RefSeq Size 8187 bp
RefSeq ORF 7626 bp
Locus ID 7094
Domains B41, I_LWEQ
Protein Families Druggable Genome
Protein Pathways Focal adhesion
MW 269.6 kDa
Gene Summary This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin.

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