pLenti-CMV-Synapsin-GFP慢病毒表達(dá)質(zhì)粒

RefSeq NM_006950.2
RefSeq Size 2248 bp
RefSeq ORF 2118 bp
Locus ID 6853
UniProt ID P17600
Cytogenetics Xp11.3-p11.23
Domains Synapsin
MW 73.9 kDa
Gene Summary This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified

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