K562-BCMA cell line藥物靶點穩定重組表達細胞株


B-Cell Maturation Antigen (BCMA), also known as tumor necrosis factor receptor superfamily member 17 (TNFRSF17) or CD269, is a type I membrane protein encoded by the TNFRSF17 gene. TNFRSF17 is a cell surface receptor of the TNF receptor superfamily, that recognizes its ligands including BAFF (B-cell activating factor) and APRIL (a proliferation inducing ligand). BCMA is preferentially expressed in mature B lymphocytes and also on Multiple Myeloma (MM) cells. In vitro, the activation of BCMA by its ligand promotes the differentiation and proliferation of B cells. A vast array of intracellular activity is involved in BCMA-induced signal transduction, including activation of the NF-κB signaling pathway. The bioactivity of BAFF and APRIL as soluble homotrimers distinguishes them from other TNFSF ligands such as TRAIL, FasL, and CD40L, which are only active as membrane-bound molecules.

The K562-BCMA recombinant cell line has been transfected with full-length human BCMA cDNA under control of a CMV promoter for high constitutive expression.

BCMA Synonym(s): tumor necrosis factor receptor superfamily member 17, B-Cell Maturation Antigen, TNFRSF17, CD269

Application(s): Functional(Report Gene) Assay
Organism: Homo sapiens, human
Tissue: bone marrow
Disease: chronic myelogenous leukemia (CML)
Age: 53 years
Gender: female
Morphology: lymphoblast
Growth Properties: suspension

Cytogenetic Analysis:
The stemline chromosome number is triploid with the 2S component occurring at
4.2%. Fifteen markers (M1 and M(15)) occurred in nearly all S metaphases. Spontaneous nonspecific
dicentrics occurred, but rarely. Unstable markers were also rarely seen. The X was disomic, and N9 was
nullisomic.
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