MDS-L human Myelodysplastic syndrome bone marrow cell line人脊髓發(fā)育不良癥骨髓細胞株

Cell line name MDS-L
Synonyms MDSL
Accession CVCL_A8QV
Resource Identification Initiative To cite this cell line use: MDS-L (RRID:CVCL_A8QV)
Comments Population: Japanese.
Characteristics: IL3 dependent.
Omics: Deep exome analysis.
Derived from sampling site: Bone marrow.
Sequence variations
Mutation; HGNC; 1833; CEBPA; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000851673; Zygosity=Heterozygous (PubMed=29955132).
Mutation; HGNC; 4768; H3C3; Simple; p.Lys28Met (c.83A>T); Zygosity=Heterozygous (PubMed=29955132).
Mutation; HGNC; 7989; NRAS; Simple; p.Gly12Ala (c.35G>C); ClinVar=VCV000219097; Zygosity=Heterozygous (PubMed=29955132).
Mutation; HGNC; 11998; TP53; Simple; c.672+1G>A; ClinVar=VCV000216078; Zygosity=Homozygous; Note=Splice donor mutation (PubMed=29955132).
Disease Myelodysplastic syndrome (NCIt: C3247)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_A647 (MDS92)
Children:
CVCL_A8QY (MDS-L-2007 ) CVCL_A8QW (MDS-L/GFP-N ) CVCL_A8QX (MDS-L/GR-GFP-N )
CVCL_A8QZ (MDS-LGF )
Sex of cell Male
Age at sampling 52Y
Category Cancer cell line

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