Bordetella pertussis strain百日咳CMCC58030

The type of challenge bacteria is another critical factor of study of animal model for pertussis. The baboon animal model conducted by Warfel et al [24] used B. pertussis strain D420, a recent clinical isolate from human infant with severe respiratory distress. In present study, CMCC58030(18323), which identified by Pearl Kendrick in the 1940s[42] was used. This stains also been used to challenge Taiwan Monkey in Huang et al’s study and showed the experimental whooping cough sighs. The recent analysis on global population structure of B. pertussis has suggested that the prevalence of B. pertussis has changed in the last 100 years worldwide, in which strain 18323 belongs to the branch contains of a small number of stains showing a long distance from the major prevalent branch[43]. However strain 18323 is still used for determination of potency for vaccines in China[44]. Surely, the prevalent stain isolated recently could provide a more powerful information, and it should be used to monitor pathogenicity difference of animal response in the future study.

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