TCF/LEF reporter-HEK293 cell line

The TCF/LEF Reporter – HEK293 Cell Line (Wnt Signaling Pathway) is designed for monitoring the activity of the Wnt/?-catenin signaling pathway. The Wnt pathway controls a large and diverse set of cell fate decisions in embryonic development, adult organ maintenance and disease. Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to stabilization and nuclear translocation of ?-catenin. ?-catenin then binds to TCF/LEF transcription factors in the nucleus, leading to transcription and expression of Wnt-responsive genes.

Supplier來源:BioVector NTCC Inc.
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