PUF60 gene基因表達質粒敲除編輯載體

RefSeq Size 1946 bp
RefSeq ORF 1680 bp
Locus ID 22827
Domains RRM, RRM_1
Protein Pathways Spliceosome
MW 59.7 kDa
Gene Summary This gene encodes a nucleic acid-binding protein that plays a role in a variety of nuclear processes, including pre-mRNA splicing and transcriptional regulation. The encoded protein forms a complex with the far upstream DNA element (FUSE) and FUSE-binding protein at the myelocytomatosis oncogene (MYC) promoter. This complex represses MYC transcription through the core-TFIIH basal transcription factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

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