Name細胞名稱：NTCC? AG08169 ALZHEIMER DISEASE, FAMILIAL, TYPE 3 | PRESENILIN 1; PSEN1 B-Lymphocyte Cell Line
家族性 3 型阿爾茨海默病 |早老素1; PSEN1細胞株
Description描述：The donor has a history of progressive memory loss beginning at age 55 preceded by 1-2 years of depression and social withdrawal. The donor exhibits global dementia with apraxia, emotional lability, and regressive reflexes. Gradual deterioration of intellectual functions has necessitated constant custodial care. The culture was initiated on 05/16/85 by transformation of lymphocytes with Epstein Barr virus. The cells grow in suspension and their morphology is spherical. The karyotype is 46,XY with 4% of the cells examined showing random chromosome loss and 2% showing random chromosomal aberrations. A skin fibroblast culture from same donor is AG08170B. Cells carry missense mutation {Ala246Glu (A246E)} in the AD3 [presenilin 1 (PSEN1)] gene. The legacy karyotype description shown in this Remark may not be representative of the current available product.
Category分類：B-Lymphocyte
ID編號:NTCC?-AG08169
Size/Quantity數量: 1 Flask/2 Vials
Biosafety Level生物安全級別:1
Shipping Info運輸方式: RT/Dry Ice
Storage儲存方式: RT/Liquid Nitrogen
Race: White
Age年齡:56 YR
Gender性別:Male
Cell Type細胞類型: ALZHEIMER DISEASE, FAMILIAL, TYPE 3 | PRESENILIN 1; PSEN1
Affected State:Yes
Product:LCL
Gene:PSEN1
Mutations突變:ALA246GLU
Ethnicity:CANADIAN
Family:964
Relationship:VII-42
Karyotype:46,XY
Tissue Type組織來源:Blood
Complete Growth Medium完全培養基: BioVector? Roswell Park Memorial Institute Medium 1640 with 2mM L-glutamine or equivalent Complete Medium
Subculturing傳代方法:
Cryopreservation凍存方法:Freeze medium: Complete growth medium supplemented with 5% (v/v) DMSO
Storage temperature: liquid nitrogen vapor phase
Culture Conditions培養條件:Atmosphere: air, 95%; carbon dioxide (CO2), 5%
Temperature: 37.0°C
STR Profile鑒定數據:
References參考文獻:

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