Cell Line Name：NTCC? PI4KIIIα Kinase Stable Cell Line激酶穩(wěn)定表達(dá)細(xì)胞株

Target藥物靶點(diǎn)：PI4KIIIα
Cat#貨號(hào):NTCC?-I-PI4KIIIα
Size/Quantity數(shù)量: 1 Flask / 2 Vials
Biosafety Level生物安全級(jí)別: 1
Shipping Info運(yùn)輸方式: RT/Dry Ice
Storage儲(chǔ)存方式: RT/Liquid Nitrogen
Application用途:Screening & Activity Analysis
Kinases play a central role in cell signaling to elicit many physiological responses. Dysregulation of kinase activity leads to many human diseases, especially cancer. A typical signaling pathway involves a kinase cascade to produce a cellular response starting with receptor activation via a ligand-induced activation step. Receptor-specific ligands, such as growth factors, result in receptor tyrosine kinases (RTK) dimerization or oligomerization. This often results in the receptors’ activation and autophosphorylation, allowing them to recruit and activate downstream mediators via their SH2 domains. This event then triggers a signaling cascade that leads to the phosphorylation and activation of downstream kinases to act upon various downstream target molecules, including several cytoplasmic targets and transcriptional factors. The activated targets elicit cellular responses that include the promotion of cell growth and division, protein translation, or other physiological responses. Product Highlights Comprehensive Portfolio – Binding and functional, cell-based assays for receptor dimerization, SH2 recruitment, and target engagement as well as over 420 kinases active, mutant, and inactive recombinant kinases for activity and biophysical testing Highly Applicable – Ideal for the development of small molecule and biologic therapeutics, from target ID through pre-clinical drug development programs, into therapeutic commercial release Clinically Relevant, Cell-Based Assays – Leverage and implement any of the NTCC? qualified or target-based bioassays to accelerate your biological candidate, whether it is a novel therapeutic or a biosimilar Rigorously Tested Kinase Enzymes – Kinase enzymes utilized in NTCC?KinaseProfiler services for screening millions of compounds over the past 30 years 激酶(kinase)是一類從高能供體分子（如ATP）轉(zhuǎn)移磷酸基團(tuán)到特定靶分子（底物）的酶；這一過程謂之磷酸化。許多腫瘤的發(fā)生是由某些與生長(zhǎng)相關(guān)的“激酶"發(fā)生突變導(dǎo)致異常活化引起的，因而針對(duì)這些突變激酶的抑制劑能夠有效抑制這些激酶的活性，從而達(dá)到抑制癌細(xì)胞增長(zhǎng)的目的。
Cell Line:
EXpress Kit:
Bioassay Kit生物檢測(cè)試劑盒:
Protein蛋白: ?
Cell Type細(xì)胞類型: Kinase Stable Cell Line
Source組織來源:
Specification規(guī)格:
Cell Images細(xì)胞圖片:
Complete Growth Medium完全培養(yǎng)基: NTCC? PI4KIIIα Stable Cells Complete Medium
Subculturing傳代方法:
Cryopreservation凍存方法:Freeze medium: Complete growth medium supplemented with 5% (v/v) DMSO
Storage temperature: RT/Liquid nitrogen vapor phase
Culture Conditions培養(yǎng)條件:Atmosphere: air, 95%; carbon dioxide (CO2), 5%
Temperature: 37.0°C
STR Profile鑒定數(shù)據(jù):
References參考文獻(xiàn):

Supplier供應(yīng)商:
BioVector質(zhì)粒載體菌株細(xì)胞蛋白抗體基因保藏中心
NTCC典型培養(yǎng)物保藏中心
Tel電話：400-800-2947
Email：Biovector@163.com
http://www.biovector.net