Cell Line Name：NTCC? FXR核激素受體穩(wěn)定表達(dá)細(xì)胞株NTCC? Nuclear Hormone Receptor Stable Cell Line

Target藥物靶點(diǎn)：FXR
Cat#貨號:NTCC?-N-FXR
Size/Quantity數(shù)量: 1 Flask / 2 Vials
Biosafety Level生物安全級別: 1
Shipping Info運(yùn)輸方式: RT/Dry Ice
Storage儲存方式: RT/Liquid Nitrogen
Application用途:Protein Interaction
Nuclear proteins are key targets for drug development due to their ubiquitous roles in controlling cellular behavior and pathway expression. The translocation of many nuclear proteins into and out of the nucleus is a highly controlled mechanism that can dictate protein function. Controlling this translocation behavior using therapeutics, or ensuring that a potential drug does not cause undesired effects on translocation, are important applications for measuring nuclear translocation. Nuclear hormone receptors (NHRs), including steroid receptors, are a critical subset of nuclear proteins that regulate gene expression in response to ligand activation and are intimately involved in endocrine pathway signaling. NHRs commonly rely on a coactivator or corepressor protein, often a steroid receptor cofactor (SRC protein), to perform their function. Enhancing or disrupting the association of these proteins can be a target for therapeutic development focused on controlling NHR-related gene expression. BioVector NTCC Inc. provides NTCC?PathHunter nuclear translocation and protein interaction cell-based, functional assays to investigate protein translocation events and activation of nuclear proteins. Nuclear translocation assays allow for studying the trafficking of your protein of interest to and from the nucleus and analyzing the pharmacological effects of therapeutics on these events. Protein interaction assays can be used to evaluate the interaction of NHRs and their cofactors, including therapeutics that affect this protein-protein interaction. 核受體（NHR）作為藥物靶點(diǎn) 核受體（NHR）是配體激活轉(zhuǎn)錄因子，參與重要的生理過程，如癌癥、糖尿病、類風(fēng)濕性關(guān)節(jié)炎、哮喘或激素抵抗綜合征。因此，核激素受體在現(xiàn)代生物醫(yī)學(xué)研究和藥物開發(fā)中具有重大意義。 核激素受體（NHR）是一種可溶性蛋白質(zhì)，可以通過與特定DNA序列相互作用來調(diào)節(jié)基因表達(dá)，使治療藥物能在轉(zhuǎn)錄水平上作用于特定靶點(diǎn)。 與其他轉(zhuǎn)錄因子相反，核受體可以通過結(jié)合到相應(yīng)的配體來調(diào)節(jié)活性，小的親脂性分子能輕易地穿透生物膜。最近幾年中確定的一些核受體不具有任何已知的配體。這些所謂的孤兒受體自從它們可能導(dǎo)致新的內(nèi)分泌調(diào)節(jié)系統(tǒng)的發(fā)現(xiàn)已吸引很多人相當(dāng)大的興趣。
Cell Line: ．
EXpress Kit:
Bioassay Kit生物檢測試劑盒:
Protein蛋白:
Cell Type細(xì)胞類型: Nuclear Hormone Receptor Stable Cell Line
Source組織來源:
Specification規(guī)格:
Cell Images細(xì)胞圖片:
Complete Growth Medium完全培養(yǎng)基: NTCC? FXR Stable Cells Complete Medium
Subculturing傳代方法:
Cryopreservation凍存方法:Freeze medium: Complete growth medium supplemented with 5% (v/v) DMSO
Storage temperature: RT/Liquid nitrogen vapor phase
Culture Conditions培養(yǎng)條件:Atmosphere: air, 95%; carbon dioxide (CO2), 5%
Temperature: 37.0°C
STR Profile鑒定數(shù)據(jù):
References參考文獻(xiàn):

Supplier供應(yīng)商:
BioVector質(zhì)粒載體菌株細(xì)胞蛋白抗體基因保藏中心
NTCC典型培養(yǎng)物保藏中心
Tel電話：400-800-2947
Email：Biovector@163.com
http://www.biovector.net