UWB1.289 NTCC?人卵巢癌細胞株

BioVector NTCC質粒載體菌株細胞蛋白抗體基因保藏中心

UWB1.289 is a human ovarian cancer cell line derived from a tumor of papillary serous histology, the most common form of ovarian carcinoma. It's particularly valuable for studying:

• BRCA1-deficient ovarian cancer: Understanding the molecular mechanisms underlying ovarian cancer development and progression in the absence of BRCA1 function.

• DNA damage response: Investigating how cells respond to DNA damage, particularly in the context of BRCA1 deficiency.

• Drug sensitivity and resistance: Studying the sensitivity of BRCA1-deficient ovarian cancer cells to various chemotherapeutic agents.

• Targeted therapies: Developing targeted therapies that exploit the vulnerabilities of BRCA1-deficient tumors.

Key characteristics of UWB1.289 cells:

• BRCA1 deficiency: Carries a germline BRCA1 mutation and has a deletion of the wild-type allele.

• Sensitive to DNA damage: Exhibits increased sensitivity to ionizing radiation and other DNA-damaging agents.

• Defective DNA repair: Impaired DNA repair mechanisms, particularly homologous recombination.

By studying UWB1.289 cells, researchers can gain valuable insights into the biology of BRCA1-deficient ovarian cancer and develop more effective treatments for patients with this aggressive form of the disease.

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BioVector NTCC質粒載體菌株細胞蛋白抗體基因保藏中心

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