GM10742 NTCC?來自Leber遺傳性視神經病變患者的類淋巴母細胞株-BioVector NTCC質粒載體菌株細胞蛋白抗體基因保藏中心

NTCC? GM10742 is a lymphoblastoid cell line derived from a patient with Leber's hereditary optic neuropathy (LHON).This genetic disorder primarily affects vision, causing sudden vision loss, often in young adults.

Key characteristics of GM10742 cells:

• Mitochondrial DNA mutation: Carries a specific mutation in the mitochondrial DNA, 11778G>A, which is associated with LHON.

  
  

• Oxidative phosphorylation defects: Impaired mitochondrial function due to the mutation.

• Model for LHON research: Useful for studying the molecular mechanisms underlying LHON and for screening potential therapeutic agents.

By studying GM10742 cells, researchers can gain valuable insights into the pathophysiology of LHON and develop strategies to prevent or treat this debilitating disease.

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