BioVector?pegCTNNB1 S45del is a genetic variant that affects the CTNNB1 gene, which provides instructions for making a protein called beta-catenin. This protein plays a role in cell adhesion and signaling pathways that control cell growth and development.

The S45del variant causes a deletion of the amino acid serine at position 45 in the beta-catenin protein. This deletion disrupts the normal function of the protein, leading to increased levels of beta-catenin in cells. Increased levels of beta-catenin can lead to uncontrolled cell growth and the development of cancer.

The S45del variant has been found to be associated with several types of cancer, including colorectal cancer, hepatocellular carcinoma, and pancreatic cancer. It is also associated with a rare inherited disorder called familial adenomatous polyposis (FAP), which causes the formation of numerous polyps in the colon and rectum.

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