重組梅毒抗原 Recombinant Treponema Pallidum (TpN15,17,47) (GST Tag)
Source：

Treponema pallidum (strain Nichols)

Cat.No.:

A02301

Tag:

GST Tag

Molecular Mass：

35.83 kDa

Expression Host：

Ecoli.

Formulation：

Purified, Liquid

Buffer：

Phosphate Buffered Saline,5%mannital,0.05% Tween20, pH7.4

Purification：

>95% pure (SDS-PAGE).

Storage:

For long term storage, the product should be stored at -20°C or lower.



Please avoid repeated freeze-thaw cycles.





Description：

Treponema pallidum, a spirochete of the family Spirochaetaceae, is the etiologic agent of venereal syphilis. Treponema pallidum has outer and cytoplasmic membranes, a thin peptidoglycan layer, and periplasmic flagella (also called endoflagella) which lie in the periplasmic space. Treponema pallidum Nichols (TpN) refers to a prefix of a nomenclature for the identification of Treponema pallidum polypepitides. TpN 15, a membrane-associated 15-kDa lipoprotein with signal peptide, induces antibody response during infection. TpN17 is a major membrane-associated 17-kDa lipoprotein with signal sequence. TpN 47, a major membrane-associated 47-kDa lipoprotein with carboxypeptidase properties, activates endothelial cells and has high immunogenicity. Reportedly, specific antibodies against the three Tp antigens have been continuously detectable in patients throughout the course of TP infection, which are considered to be the most promising for clinical appilication.











圖 重組TpN15-17-47結構設計





















參考文獻：
[1] Walker EM, et al. 1995. J Bacteriol. 177(7):1797-804.

[2] Norris SJ, et al. 1993. Microbiol Rev. 57(3):750-79.

[3] Sun AH, et al. 2009. Clin Chem Lab Med. 47(3):321-6.

[4]Talha SM, et al. 2013. PLoS One. 8(12):e84050.
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