A2780/cDDP NTCC?人源卵巢癌順鉑耐藥細胞株human ovarian cancer cisplatin resistant cell line

BioVector NTCC質粒載體菌株細胞蛋白抗體基因保藏中心

A2780/cDDP refers to a specific type of human ovarian cancer cell line that has developed resistance to cisplatin (also known as CDDP).

A2780 is the original ovarian cancer cell line. It was established from a patient with ovarian endometroid adenocarcinoma who had not received any prior chemotherapy. This cell line is widely used in cancer research as a model to study ovarian cancer biology and test the effectiveness of various chemotherapeutic drugs.

A2780/cDDP cells were derived from the parental A2780 cell line by exposing them to increasing concentrations of cisplatin over time. This process allowed the cells to develop resistance mechanisms to overcome the cytotoxic effects of the drug.

Significance of A2780/cDDP:

• Understanding Cisplatin Resistance: These cells provide a valuable model to investigate the mechanisms underlying cisplatin resistance in ovarian cancer. Studying these mechanisms can lead to the development of new strategies to overcome drug resistance and improve treatment outcomes for patients.

• Drug Discovery: A2780/cDDP cells can be used to screen new chemotherapeutic agents that may be effective against cisplatin-resistant ovarian cancer.

• Preclinical Studies: These cells can be used in preclinical studies to evaluate the efficacy and safety of new treatment approaches, such as targeted therapies or immunotherapies.

Key Points:

• A2780/cDDP cells represent a valuable tool for cancer research.

• They provide insights into the mechanisms of cisplatin resistance in ovarian cancer.

• These cells can be used to develop new and more effective treatments for this challenging disease.

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