GIL77 BioVector?三萜烯化合物生產用羊毛甾醇合酶缺陷型酵母突變株Saccharomyces cerevisiae ERG7 lanosterol synthase deficient strain

BioVector NTCC質粒載體菌株細胞蛋白抗體基因保藏中心

The GIL77 strain is a genetically modified strain of Saccharomyces cerevisiae (baker's yeast) commonly used in research.

Key Characteristics:

• Lanosterol Synthase Deficiency:The defining feature of the GIL77 strain is a deficiency in lanosterol synthase, an enzyme crucial for ergosterol biosynthesis.Ergosterol is a vital component of the yeast cell membrane.

  
  

• Genetic Background: GIL77 has a specific genetic background, often including mutations in genes involved in galactose metabolism and heme biosynthesis.

Applications:

• Triterpenoid Biosynthesis:Due to its lanosterol synthase deficiency, the GIL77 strain is widely used as a host for heterologous expression of triterpene synthases from various plant and microbial sources. By introducing genes encoding these enzymes into GIL77, researchers can study the biosynthesis of triterpenoids, a diverse class of natural products with various biological activities.

  
  

• Metabolic Engineering:The GIL77 strain serves as a platform for metabolic engineering studies aimed at optimizing the production of valuable triterpenoids in yeast.

  
  

Significance:

The GIL77 strain has become an important tool in biotechnology and natural product research. Its unique genetic background and ability to produce various triterpenoids have enabled significant advancements in our understanding of triterpene biosynthesis and have paved the way for the development of microbial production platforms for these valuable compounds.

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