Fet3 Fet4 mutant yeast strainBioVector?鐵轉運缺陷型酵母突變菌株

BioVector NTCC質粒載體菌株細胞蛋白抗體基因保藏中心

• fet3fet4 mutant: This refers to a specific strain of the yeast Saccharomyces cerevisiae that lacks functional copies of the FET3 and FET4 genes.

• Iron Acquisition:

  • FET3 encodes a high-affinity iron transporter protein located in the plasma membrane.

  • FET4 encodes a ferroxidase, an enzyme that oxidizes ferrous iron (Fe2+) to ferric iron (Fe3+). This oxidation is crucial for efficient iron uptake by the FET3 transporter.

• Phenotype:

  • The fet3fet4 mutant strain is severely impaired in its ability to acquire iron from the environment.

  • This iron deficiency leads to growth defects and other physiological abnormalities.

• Research Significance:

  • The fet3fet4 mutant is a valuable model system for studying:

    • Iron homeostasis and transport in eukaryotic cells.

    • The impact of iron deficiency on cellular processes.

    • The interaction between iron metabolism and other cellular pathways.

    
    

• Applications:

  • The fet3fet4 mutant is used in various research areas, including:

    • Investigating the molecular mechanisms of iron uptake and transport.

    • Screening for compounds that can improve iron uptake in iron-deficient conditions.

    • Developing strategies to enhance the bioavailability of iron in plants and animals.

    
    

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