AML-venetoclax NTCC?人急性髓系白血病細胞維奈克拉耐藥細胞株resistant cell line

BioVector NTCC質粒載體菌株細胞蛋白抗體基因保藏中心

AML-venetoclax resistant cell line is a type of laboratory-grown cell that has developed the ability to survive and proliferate despite being exposed to venetoclax, a drug used to treat acute myeloid leukemia (AML). These cell lines are valuable research tools because they can help scientists understand the mechanisms of venetoclax resistance and identify potential strategies to overcome it.

Several mechanisms of venetoclax resistance have been identified in AML cell lines, including:

• Increased expression of MCL1:MCL1 is a protein that can inhibit apoptosis, or programmed cell death. When MCL1 levels are high, it can counteract the effects of venetoclax, which works by promoting apoptosis in AML cells.

  
  

• Mutations in BCL2:BCL2 is the protein that venetoclax targets.Mutations in BCL2 can make it less susceptible to venetoclax, allowing AML cells to survive.

  
  

• Changes in mitochondrial function: Mitochondria are the "powerhouses" of cells.Changes in mitochondrial function can help AML cells resist apoptosis, even in the presence of venetoclax.

  
  

AML-venetoclax resistant cell lines are being used to study these mechanisms of resistance and to develop new drugs and therapies that can overcome them. For example, researchers are investigating the use of MCL1 inhibitors in combination with venetoclax to target AML cells that have become resistant to venetoclax alone.

In addition to their use in basic research, AML-venetoclax resistant cell lines can also be used to:

• Test new drugs and therapies: Researchers can use these cell lines to screen new drugs and therapies for their ability to kill AML cells that are resistant to venetoclax.

• Develop personalized treatment plans: By understanding the specific mechanisms of resistance in a patient's AML cells, researchers may be able to develop personalized treatment plans that are more likely to be effective.

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