MODE-K NTCC?小鼠十二指腸上皮細胞株mouse intestinal epithelial cell line

BioVector NTCC質(zhì)粒載體菌株細胞蛋白抗體基因保藏中心

The NTCC? MODE-K cell line is a valuable tool for studying intestinal epithelial cell function, particularly in the context of mucosal immunity and gluten toxicity. Here are some key aspects:

• Origin: Derived from the mouse duodenum.

• Characteristics:

  • Immortalized by the SV40-large T gene.

  • Retains key features of intestinal epithelial cells.

  • Can express MHC class II molecules upon stimulation with interferon-gamma, allowing for antigen presentation.

  
  

• Applications:

  • Mucosal Immunology: Investigating interactions between intestinal epithelial cells and immune cells.

  • Gluten Toxicity: Studying the mechanisms of gluten-induced damage in celiac disease.

  • Drug Development: Screening for compounds that modulate intestinal epithelial cell function or protect against gluten toxicity.

  
  

Key Points:

• MODE-K cells provide a valuable in vitro model for studying intestinal epithelial cell biology.

• Their ability to express MHC class II molecules makes them useful for investigating immune responses in the gut.

• Research using MODE-K cells contributes to our understanding of intestinal diseases and the development of new therapies.

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生產(chǎn)廠家Supplier:

BioVector NTCC質(zhì)粒載體菌株細胞蛋白抗體基因保藏中心

E-mail:BioVector@163.com

http://www.biovector.net