CD19 knockout Nalm6-luciferase NTCC?人B細胞前體急性淋巴細胞白血病細胞株human B-cell precursor acute lymphoblastic leukemia (ALL) cell line

BioVector NTCC質粒載體菌株細胞蛋白抗體基因保藏中心

The NTCC? CD19 knockout Nalm6-luciferase cell line is a valuable tool for research in immunology and oncology. Here's a breakdown of its key features and significance:

Key Features:

• Nalm6 Origin: Derived from the Nalm6 cell line, a human B-cell precursor acute lymphoblastic leukemia (ALL) cell line.

• CD19 Knockout: The CD19 gene, which encodes a protein essential for B-cell development and function, has been genetically removed using CRISPR/Cas9 technology.

• Luciferase Expression: The cell line constitutively expresses firefly luciferase, allowing for non-invasive monitoring of cell growth and proliferation using bioluminescence imaging techniques.

Significance in Research:

1. Studying CD19 Function: The CD19 knockout enables researchers to investigate the role of CD19 in B-cell development, signaling pathways, and immune responses.

2. Cancer Research:

   • Modeling B-cell Malignancies: The cell line can serve as a model for B-cell malignancies, such as B-ALL, that express CD19.

   • Evaluating CD19-Targeted Therapies: The CD19 knockout can be used to assess the efficacy of CD19-targeted therapies, such as chimeric antigen receptor (CAR) T-cell therapies, which are revolutionizing cancer treatment.

   
   

3. Drug Discovery: The cell line can be used to screen for new drugs that target B-cell malignancies or modulate B-cell function.

Applications:

• Immunology Research: Studying B-cell development, differentiation, and function.

• Oncology Research: Investigating B-cell malignancies, evaluating CD19-targeted therapies, and screening for new anticancer drugs.

• Drug Discovery: Identifying and developing novel therapeutic agents for B-cell-related diseases.

Note:

• The use of this cell line requires appropriate safety measures in the laboratory, as it involves working with genetically modified organisms.

• The characteristics and behavior of the CD19 knockout Nalm6-luciferase cell line can be influenced by various factors, such as culture conditions and the presence of other cells or factors in the environment.

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