NTCC? LX-2Human Hepatic Stellate Cell Line

Cat No.: NTCC2274825

The NTCC? LX-2 human hepatic stellate cell line has been extensively characterized and retain key features of hepatic stellate cytokine signaling, neuronal gene expression, retinoid metabolism, and fibrogenesis , making them a highly suitable model of human hepatic fibrosis.

NTCC? LX-2 cells Images:

Alternate Names

HSC

Perisinusoidal cells

Ito cells

Hepatic lipocytes

Hepatic pericytes

Background Information

Hepatic stellate cells are a major cell type responsible for liver fibrosis following their activation into fibrogenic myofibroblast-like cells in diseases such as chronic alcoholism, hepatitis B and C, fatty liver disease, obesity and diabetes. There is an increasing need for renewable cell culture models that faithfully recapitulate their in vivo phenotype, particularly for human studies.

NTCC? LX-2was generated by immmortalization of primary human hepatic stellate cells with the SV40 large T antigen followed by selective culture of early passaged cells in low serum media conditions.

Immortalized NTCC? LX-2was established by Xu et al to overcome issues of culture variability and to provide a stable and unlimited source of human hepatic stellate cells that are homogeneous. These cell lines have been extensively characterized and retain key features of cytokine signaling, neuronal gene expression, retinoid metabolism, and fibrogenesis, making them highly suitable for culture based studies of human hepatic fibrosis.

Application

The NTCC? LX-2human hepatic stellate cell line has been extensively characterized and retain key features of hepatic stellate cytokine signaling, neuronal gene expression, retinoid metabolism, and fibrogenesis , making them a highly suitable model of human hepatic fibrosis.

Quality Assurance

? Each vial contains ≥ 1X10^6 viable cells.

? Cells are tested by PCR and are negative for Hepatitis A, B, C and HIV-1 & 2 viruses.

? Cells are negatrive for mycoplasma contamination.

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Usage Statement

This product contains genetically modified organisms (GMO). Within the EU GMOs are regulated by Directives 2001/18/EC and 2009/41/EC of the European Parliament and of the Council and their national implementation in the member States respectively. This legislation obliges BioVector NTCC Inc. to request certain information about you and the establishment where the GMOs are being handled.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

[Cell Designation細胞株名稱] LX-2
[Organism物種來源] NCBI_TaxID=9606; ! Homo sapiens
[Disease疾病種類]
[Accession Num編號] CVCL_5792
[Comments相關資料]
[Reference參考文獻]
[Category分類] Transformed cell line
[Date創建時間] Created: 04-04-12; Last updated: 20-05-21; Version: 17
[Synonyms別名]
[Hierarchy]
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完全培養基及血清：
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